The Efficacy of an Avian Metapneumovirus Vaccine Applied Simultaneously with Infectious Bronchitis and Newcastle Disease Virus Vaccines to Specific-Pathogen-Free Chickens

2007 ◽  
Vol 51 (2) ◽  
pp. 594-596 ◽  
Author(s):  
I. Tarpey ◽  
M. B. Huggins ◽  
S. J. Orbell
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Specific Pathogen Free ◽  
Avian Metapneumovirus ◽  
Infectious Bronchitis ◽  
Specific Pathogen

scholarly journals Pathogenesis of Renal Lesions in Chickens After Experimental Infection With 9a5b Newcastle Disease Virus Mutant Isolate

2016 ◽  
Vol 54 (1) ◽  
pp. 94-98 ◽  
Author(s):  
A. El-Bahrawy ◽  
A. Zaid ◽  
Y. Sunden ◽  
M. Sakurai ◽  
H. Ito ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Kidney Tissue ◽  
Rt Pcr ◽  
Tissue Samples ◽  
Infectious Bronchitis ◽  
Avian Nephritis Virus ◽  
Specific Pathogen ◽  
Virus Mutant

In this study, we investigated the pathogenesis of Newcastle disease virus (NDV) in the chicken kidney. Twenty-six 32-day-old specific pathogen-free chickens were intranasally inoculated with the 9a5b NDV mutant isolate. Kidney tissue samples, collected at 6 and 12 hours postinoculation (hpi) and 1, 2, 3, 5, and 10 days postinoculation (dpi), were analyzed by histopathology, immunohistochemistry (IHC), reverse transcription polymerase chain reaction (RT-PCR), and virus titration. Histopathologically, tubulointerstitial nephritis was detected in the renal cortex and predominantly in the medulla. Nephrotropism of 9a5b NDV was confirmed by IHC, RT-PCR, and virus isolation. Massive degenerative changes and infiltration of CD3-immunopositive cells accompanied replication of the 9a5b NDV isolate in chicken kidneys. In conclusion, pathological changes that were caused by NDV in chicken kidneys were similar to those caused by avian influenza virus, infectious bronchitis virus, and avian nephritis virus, and this highlights the importance of including NDV in the differential diagnosis of kidney disease in chickens.

scholarly journals Immunogenicity and Safety of La Sota Strain of Newcastle Disease Virus Administered to Newly Hatched Chicks by Nebulization

2009 ◽  
Vol 78 (1) ◽  
pp. 137-144 ◽  
Author(s):  
Hrvoje Mazija ◽  
Stanislav Čajavec ◽  
Estella Prukner-Radovčić ◽  
Neda Ergotić ◽  
Irena Ciglar-Grozdanić ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Specific Pathogen Free ◽  
Delivery Method ◽  
Closed Chamber ◽  
Specific Pathogen ◽  
Backyard Flocks ◽  
The Given ◽  
Commercial Chickens

The objective of four trials performed on specific-pathogen-free and commercial chickens, either of light or heavy hybrids, was to evaluate the new vaccine delivery method to newly hatched chickens using commercial La Sota vaccine. The vaccine was given by means of nebulization using an ultrasonic device producing homologous aerosol of particles ranging 3–5 microns in diameter. Chickens were exposed to the La Sota vaccine for 30, 60 or 300 s in a closed chamber of the device, thus enabling constant particle size during vaccination. No adverse reaction to the given vaccine was recorded, and the immunity, developed no later than 7 days after vaccination, lasted for at least 49 days which was confirmed by challenge infection using Herts 33 strain of Newcastle disease virus. Maternal antibodies did not influence the development of immunity. Regarding the mode of vaccination, the described method is suitable for the control of Newcastle disease in both big poultry enterprises as well as small backyard flocks when newly hatched chickens are supplied from local hatcheries.

scholarly journals Newcastle disease virus induces testicular damage and disrupts steroidogenesis in specific pathogen free roosters

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Zaib Ur Rehman ◽  
Shanhui Ren ◽  
Bin Yang ◽  
Xiaofeng Yang ◽  
Salman Latif Butt ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Specific Pathogen Free ◽  
Testicular Damage ◽  
Specific Pathogen

scholarly journals Construction and Immunogenicity of Novel Chimeric Virus-Like Particles Bearing Antigens of Infectious Bronchitis Virus and Newcastle Disease Virus

Viruses ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 254 ◽  
Author(s):  
Xuan Wu ◽  
Xiwen Zhai ◽  
Yan Lai ◽  
Lei Zuo ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Infectious Bronchitis Virus ◽  
Newcastle Disease ◽  
Vaccine Platform ◽  
Virus Like Particles ◽  
Infectious Bronchitis ◽  
Specific Pathogen ◽  
Virulent Challenge ◽  
Carboxy Terminal

Infectious bronchitis virus (IBV) and Newcastle disease virus (NDV) are two poultry pathogens seriously affecting the poultry industry. Here, IBV S1 and the ectodomain of NDV F proteins were separately linked with the trans-membrane and carboxy-terminal domain of IBV S protein (STMCT), composing rS and rF; thus, a novel chimeric infectious bronchitis-Newcastle disease (IB-ND) virus-like particles (VLPs) vaccine containing the rS, rF, and IBV M protein was constructed. Under the transmission electron microscope (TEM), VLPs possessing similar morphology to natural IBV were observed. To evaluate the immunogenicity of chimeric IB-ND VLPs, specific pathogen-free (SPF) chickens were immunized with three increasing doses (50, 75, and 100 μg protein of VLPs). Results of ELISAs detecting IBV and NDV specific antibodies and IL-4 and IFN-γ T cell cytokines indicated that vaccination with chimeric IB-ND VLPs could efficiently induce humoral and cellular immune responses. In the challenge study, chimeric IB-ND VLPs (100 μg protein) provided 100% protection against IBV or NDV virulent challenge from death, and viral RNA levels in tissues and swabs were greatly reduced. Collectively, chimeric IB-ND VLPs are highly immunogenic and could provide complete protection from an IBV or NDV virulent challenge. Chimeric IB-ND VLPs are an appealing vaccine candidate and a promising vaccine platform bearing multivalent antigens.

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